Co-occurrence of immature T-lymphoblastic lymphoma and acute myeloid leukemia—microenvironment-dependent lineage differentiation derived from a common progenitor?

Lineage switch from acute lymphoblastic leukemia to myeloid leukemia

DETERMINATION OF A SHARED EPITOPE ON CELLS FROM ACUTE MYELOGENIC LEUKEMIA (AML) AND T-ACUTE LYMPHOBLASTIC LEUKEMIA ( T-ALL)

Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing BALBI c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and 4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and acute myelogenous leukemia (AML) patients as well as leukemic cells from pat...

Significance of Cross Lineage Antigen Expression in Acute Lymphoblastic Leukemia

Background: Aberrant expression of cross-lineage antigens gives valuable insight into the diagnosis and prognosis of acute leukemia. In countries like India, cytogenetic tests are widely accessible. Exploring the prognostic value of an accessible test is of great importance. Therefore, establishing a population-specific immunophenotype database will enable to design an antibody panel equipped t...

Acute lymphoblastic leukemia/lymphoblastic lymphoma of natural killer (NK) lineage: quest for another NK-lineage neoplasm.

Joanne M. Wroblewski lez-Garcia M, Koedens M, Fukunga N, Davidson B, Dick J, Minn A, Boise L, Thompson C, Wicha M, Nunez G: A recombinant bclL. Travis Lay xs adenovirus selectively induces apoptosis in cancer cells but not Timothy C. Meeker in normal bone marrow cells. Proc Natl Acad Sci USA 92:11024, Markey Cancer Center 1995 University of Kentucky 4. Wroblewski J, Lay L, Van Zant G, Phillips ...

CD56 in T-cell acute lymphoblastic leukaemia: a malignant transformation of an early myeloid-lymphoid progenitor?

Concerning biological and clinical aspects,T-cell acute lymphoblastic leukemia is now considered to be a heterogeneous disorder. Here we analyze the impact of particular phenotypic patterns on prognosis of 30 cases of T-cell ALL; poor response to induction treatment and short survival were observed in patients who expressed CD56. The antigen profile of these cases suggests a malignant transform...